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# iPSpine

Developing a novel therapy for lower back pain

## Sitemaps

- [XML Sitemap](https://ipspine.eu/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [iPSpine PhDs Theses Decoded: Recent Grads Explain Their Research](https://ipspine.eu/ipspine-phds-theses-decoded-recent-grads-explain-their-research/) - Ever wondered what groundbreaking discoveries are hidden in an iPSpine PhD? Lisanne Laagland and Xiaole Tong graduated earlier this year and take you behind the scenes of their research in just a few minutes! See their video's here >>
- [Double iPSpine PhD graduation](https://ipspine.eu/double-ipspine-phd-graduation/) - On March 20th and 24th, Lisanne Laagland and Xiaole Tong completed and defended their PhD at Utrecht University! Lisanne's thesis entitled “Breaking the Vicious Circle of Nucleus Pulposus Degeneration: Exploring Advanced Treatment Options for Lower Back Pain“ included findings that highlight that the combination of factors derived of healthy disc tissue together with a suitable
- [iPSpine's Final Consortium Meeting!](https://ipspine.eu/ipspines-final-consortium-meeting/) - [Utrecht, The Netherlands] – The iPSpine Consortium is excited to announce that the Final Consortium Meeting, that took place last May, was a great success. This event, with more than 50 attendees, marks the culmination of an incredible 66-month project, which brought together 22 partners from across Europe . The consortium, coordinated by Prof. Dr. Marianna
- [iPSpine Patient Symposium](https://ipspine.eu/ipspine-patient-symposium/) - What does the current treatment landscape for lower back pain look like and what are the challenges? Is there a cure for chronic back pain on the horizon? On Tuesday April 16th, lower back pain patients, researchers and medical professionals came together to address these topics and to learn more about the recent advances of
- [iPSpine's Patient Symposium 2024](https://ipspine.eu/ipspine-hosts-a-patient-symposium/) - Days Hours Minutes Seconds This symposium is open for registrations. Fill out our registration form here. *We will only have 30 spots so secure yours before they run out! Chronic lower back pain (LBP) stands as a formidable global health challenge, affecting millions of individuals of all ages and backgrounds each year. Chronic LBP impacts quality
- [iPSpine Café - The basics of stem cells and their role within the iPSpine project](https://ipspine.eu/ipspine-cafe-the-basics-of-stem-cells-and-their-role-within-the-ipspine-project/) - Lisanne Laagland from Utrecht University presents on: The basics of stem cells and their role within the iPSpine project.During this iPSpine café you will learn more about different types of stem cells and their characteristics. It will also shed light on what the role of induced pluripotent stem cells are within the iPSpine project and
- [Understanding how material of healthy intervertebral disc cells can be used as therapy for back pain](https://ipspine.eu/understanding-how-material-of-healthy-intervertebral-disc-cells-can-be-used-as-therapy-for-back-pain/) - Many individuals endure persistent lower back pain attributed to e.g. the natural wear and tear of intervertebral discs. Before these discs undergo deterioration, there's a shift in the main cell types located in the nucleus pulposus, which is the central core of the disc. This transition involves a change from notochordal cells to nucleus pulposus cells.
- [iPSpine attends NLSEV - Netherlands Society for Extracellular Vesicles 2023!](https://ipspine.eu/🌟-exciting-update-from-ipspine-project-at-nlsev-netherlands-society-for-extracellular-vesicles-nlsev-2023/) - We’re thrilled to share insights from, Josette van Maanen, who presented her research as a poster at the Annual Meeting of the Society for Extracellular Vesicles this year.The research focuses on “The effect of notochordal cell-derived extracellular vesicles on degenerated intervertebral disc tissue,” showcasing groundbreaking work from our collaboration with Sheffield. The study explores the remarkable
- [Breakthrough Technology for Studying Extracellular Vesicles in Regenerative Medicine](https://ipspine.eu/breakthrough-technology-for-studying-extracellular-vesicles-in-regenerative-medicine/) - Stem cells play a pivotal role in regenerative medicine because of their unique ability to transform into many different cell types within the body. This allows them to repair and replace damaged or diseased tissues and organs, and offers the potential for groundbreaking treatments and therapies. However, safety concerns and complicated regulatory pathways limit their use in the clinic. As an alternative, researchers are now exploring extracellular vesicles (EVs) and their potential to treat a variety of medical conditions. EVs are secreted by all the body’s cells, including stem cells, and have gained attention for their potential to influence the behaviour of cells within the body. These tiny vesicles play a crucial role in cell communication and can influence cell behaviour, such as growth and differentiation. What makes them particularly appealing in regenerative medicine is that they share similarities with stem cells but don't possess tumorigenic potential, meaning they don’t have the risk of uncontrolled cell growth and division that commonly leads to cancer. Cells are usually studied by researchers using traditional methods such as Western blotting but since EVs are so small, very large amounts of them are required for analysis, making these usual methods difficult to use. In this paper by Josette C. van Maanen and colleagues, they discuss a cutting-edge technology called DigiWest, which offers a powerful new tool for studying EVs and has the potential to change the way EVs are analysed.
- [Investigating Back Pain: Shedding Light on Modic Changes ](https://ipspine.eu/investigating-back-pain-shedding-light-on-modic-changes/) - Chronic low back pain is the leading cause of years lived with disability in humans worldwide. It entails persistent discomfort in the lower region of the spine, often impairing mobility, reducing quality of life, and causing substantial suffering. While it is difficult to pinpoint the specific cause of this ailment, in humans it is commonly associated with degenerative changes in the spinal discs - small shock-absorbing cushions that separate vertebrae, the bones comprising the spine. Understanding the combination of factors that contribute to this condition has been a longstanding challenge, leading to a recent study by Martijn Beukers and colleagues. By closely investigating alterations within spinal structures, their research sheds light on potential triggers for chronic low back pain, with a particular focus on a phenomenon called “Modic changes.”
- [iPSpine café - Mimicking the human spine in the lab](https://ipspine.eu/ipspine-cafe-mimicking-the-human-spine-in-the-lab/) - Dr. Elias Salzer studied biomedical engineering and tissue engineering in Vienna, Austria and joined to group of Prof. Keita Ito for his PhD at the TU Eindhoven in the Netherlands.Previously, he worked with different biomaterials, cells, and bioreactors in the field of tissue engineering, always on the cutting edge of biology and technology. During this
- [iPSpine's Patient Advisory Board at PCST](https://ipspine.eu/ipspines-pab-at-pcst/) - Earlier this year, iPSpine attended the PCST conference in Rotterdam! A conference all about creating common ground, PCST focused on the discovery of science communication at the heart of scientific and technological development. The iPSpine patient advisory board has been hard at work in its efforts to support patient-driven research through the power of science communication.
- [Unpacking our Portable Spine Tester](https://ipspine.eu/unpacking-our-portable-spine-tester/) - Watch the unpacking of our new portable spine tester in Rome! ⚙️This miniaturized machine measures the range of motion of spinal segments and applies pure moments in three motion planes via three separate DC motors, enabling precise measurements. 📏Our optical motion tracking system records each spinal segment’s resulting motion, allowing us to determine the range of motion
- [iPSpine Portable Spine Tester - Shipment](https://ipspine.eu/ipspine-portable-spine-tester-packing/) - 📢 Introducing the iPSpine project’s new portable spine tester, revolutionizing biomechanical research! Accurately measuring spinal unit motion, our advanced machine eliminates the need for frozen specimens and expands experimental possibilities. This machine has been meticulously assembled and securely packed into a custom-made transportation box, ready for its journey to Rome. Watch our video below to see how it was
- [New Publication: Exploring Responsible Innovation in Stem Cell Research: Tackling Complex Ethical and Social Challenges](https://ipspine.eu/new-publication-exploring-responsible-innovation-in-stem-cell-research-tackling-complex-ethical-and-social-challenges/) - Stem cells are unique cells that garner a lot of scientific and ethical attention. They have the potential to develop into many different types of cells in the body, making them an exciting avenue for developing new treatments for a range of diseases and conditions, including chronic lower back pain. However, the use of stem
- [New Publication: Standardising the Study of Spine Disc Cells](https://ipspine.eu/new/) - Intervertebral discs play a critical role in the functioning of the human spine. They provide stability, flexibility, and withstand normal daily loads to protect the spine from injury. At the centre of each disc is the nucleus pulposus, a gel-like substance that provides resistance to load. To gain a better understanding of this crucial component
- [Reviewing Clinical Trial Trends in Tissue-Engineered Products ](https://ipspine.eu/reviewing-clinical-trial-trends-in-tissue-engineered-products/) - Chronic lower back pain is the leading cause of disability and morbidity worldwide. Degeneration of the spine’s intervertebral discs (IVDs) is a common cause of chronic lower back pain and accounts for about 40% of all cases. IVDs are structures that are embedded in the spine, and when healthy, they provide cushioning during movement. Current
- [New Publication: Improving cell-based therapies for intervertebral disc degeneration: Enhancing the culture conditions of spine cells improves their regenerative capacity](https://ipspine.eu/improving-cell-based-therapies-for-intervertebral-disc-degeneration-enhancing-the-culture-conditions-of-spine-cells-improves-their-regenerative-capacity/) - Degeneration of intervertebral discs (IVDs) is a common cause of chronic LBP. Adding nucleus pulposus cells to degenerated IVDs could promote regeneration.
- [New publication: Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients](https://ipspine.eu/new-publication-roles-and-responsibilities-in-stem-cell-research-a-focus-group-study-with-stem-cell-researchers-and-patients/) - The ethics surrounding stem cell research has been a heavily debated topic. Some of the biggest concerns surround the roles and responsibilities. What happens when something goes wrong? And who handles policy challenges? How can patients and researchers contribute to the responsible innovation of stem cell research? Currently, neither the patient nor the researcher can
- [2020/21 NWA-ORC Grant](https://ipspine.eu/2022-nwa-orc-grant/) - We are proud to announce that Prof. Dr. Keita Ito has received an NWA-ORC Award! Within iPSpine, Keita Ito leads the workpackage on in vitro/ex vivo testing of biomaterials and cells. He works towards the project’s goal to create an advanced therapy medicinal product (ATMP) for chronic lower back pain caused by the degeneration of the spine’s
- [New publication: Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration](https://ipspine.eu/notochordal-cellbased-treatment/) - New publication: Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration While chronic lower back pain interferes with simple activities of daily life such as sitting, standing, and walking, it also severely impacts one’s ability to work. Current first-line treatments are diverse and range from lifestyle changes to pain medication, with surgery as
- [iPSpine researchers give virtual lab tours](https://ipspine.eu/ipspine-researchers-give-virtual-lab-tours/) - Are you curious about what our work looks like behind the scenes? Join us on virtual lab tours by different iPSpine researchers and take a look inside our daily lab life!We will be adding more videos to this page regularly, stay tuned! Click here to watch
- [New publication: Recognizing the ethical implications of stem cell research: A call for broadening the scope](https://ipspine.eu/new-publication-recognizing-the-ethical-implications-of-stem-cell-research-a-call-for-broadening-the-scope/) - Funding information: H2020 European Institute of Innovation and Technology, Grant/Award Number: The research has been supported by the iPSpine H2020 project (https://ipspine.eu) under the contract #825925.; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Grant/Award Number: 310030E_192674/1.
- [New publication: A comprehensive tool box for large animal studies of intervertebral disc degeneration](https://ipspine.eu/new-publication-a-comprehensive-tool-box-for-large-animal-studies-of-intervertebral-disc-degeneration/) - Funding information: H2020 European Institute of Innovation and Technology, Grant/Award Number: The research has been supported by the iPSpine H2020 project (https://ipspine.eu) under the contract #825925.; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Grant/Award Number: 310030E_192674/1.
- [News item: The road to a treatment for humans and man’s best friend with lower back pain](https://ipspine.eu/news-item-the-road-to-a-treatment-for-humans-and-mans-best-friend-with-lower-back-pain/) - The article below was originally written in Dutch and was published in the June 2021 issue of the member magazine of the ‘Dutch Society of Backpain Patients’ (Nederlandse Vereniging Voor Rugpatienten, NVVR, https://www.ruginfo.nl/). Innovative research to rejuvenate our backs Although chronic low back pain can have multiple causes, ‘wear and tear’ of the intervertebral disc
- [Learn about Biomaterials](https://ipspine.eu/learn-about-biomaterials/) - NUI Galway’s CÚRAM Research Centre has created a 4-course series introducing the fundamental elements of biomaterials. Biomaterials are an integral part of the iPSpine technology. The engineered cells need an environment that mimics the native healthy tissue in order to thrive. For this purpose, biomaterials that contain tissue-specific components, and as such can provide such
- [Meet our new PAB Member, Koert Hommel](https://ipspine.eu/new-pab-member-koert-hommel/) - Meet our new PAB Member Koert Hommel! Koert Hommel has a background in travel industry and international cooperation. He worked at JoHo’s marketing department and coordinated several youth talent development programs, together with the Dutch Ministry of Foreign Affairs. Currently Koert is unemployed due to chronic lower back issues. He has been experiencing lower back pain
- [New publication: Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential](https://ipspine.eu/new-publication/) - Funding information: H2020 European Institute of Innovation and Technology, Grant/Award Number: The research has been supported by the iPSpine H2020 project (https://ipspine.eu) under the contract #825925.; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Grant/Award Number: 310030E_192674/1.
- [Patient Advisory Board Summary, Month 24](https://ipspine.eu/patient-advisory-board-summary-month-24/)
- [iPSpine Newsletter, Month 24](https://ipspine.eu/ipspine-newsletter-month-24/) - We are wrapping up the 2nd year of iPSpine! Curious about the progress we've made? Check out our newsletter, https://ipspine.eu/newsletter-month-24/ which includes: -Scientific Progress -Meetings -Patient Engagement -Advice & Exploitation -Message from our Coordinator
- [New Publication: Non-viral Gene Delivery Methods for Bone and Joints](https://ipspine.eu/new-publication-non-viral-gene-delivery-methods-for-bone-and-joints/) - Our iPSpine team members, Dr. Benjamin Gantenbein and Julien Guerrero at UBern, and colleagues have published a novel review on non-viral therapy in bone and joints in Frontiers in Bioengineering and Biotechnology! Check it out here: http://journal.frontiersin.org/article/10.3389/fbioe.2020.598466/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Bioengineering_and_Biotechnology&id=598466…
- [iPSpine in Pain Alliance Europe Newsletter](https://ipspine.eu/ipspine-in-pain-alliance-europe-newsletter/) - We are delighted to partner with Pain Alliance Europe (PAE), A Pan-European organisation of 43 associations in 19 countries, representing over 400 000 individual chronic pain. The Vice President of the PAE, Liisa Jutila, joined our Patient Advisory Board in 2020. They have featured iPSpine in their year-end newsletter. Read the article here: https://pae-eu.eu/ipspine-developing-a-novel-therapy-for-chronic-lower-back-pain/
- [iPSpine Virtual Consortium Meeting- September 15th](https://ipspine.eu/ipspine-virtual-consortium-meeting-september-15th/) - On September 15th 2020, iPSpine partners came “virtually” together to share their most recent findings and reflect on the progression of the iPSpine project. The consortium was updated on the progress within the work packages as well as the plans for the upcoming months. The generation and characterization of iPS-notochordal cells and the smart biomaterials
- [The world of ATMPs-- courses available now!](https://ipspine.eu/the-world-of-atmps-courses-available-now/) - Our partners at Pharmalex have provided two courses on advanced thereapy medicinal products (ATMPs). Put your learning hats on and check them out here:
- [The ugly, bad and good side of COVID-19 for iPSpine PhDs and post-docs](https://ipspine.eu/the-ugly-bad-and-good-side-of-covid-19-for-ipspine-phds-and-post-docs/) - How are PhD students and post docs of iPSpine all around Europe affected by the current global pandemic? Everyone is affected by the measurements taken by various states to prevent spreading of the SARS-CoV-2 virus, including members of international research consortia such as iPSpine. In our consortium, there are experts from universities and companies from
- [Zoe Bacon, back pain patient advocate, shares a story on taking back control](https://ipspine.eu/zoe-bacon-back-pain-patient-advocate-shares-a-story-on-taking-back-control/) - Our Patient Advisory Board member, Zoe Bacon, has written an inspiring and positive blog about living with two rare diseases; mixed connective tissue disease (MCTD) and fowlers syndrome. She talks about the ways she takes back control! Read her story here: https://www.rareyouthrevolution.com/post/be-your-voice
- [iPSpine Patient Advisory Board (PAB)](https://ipspine.eu/patient-advisory-board-pab/) - The Patient Advisory Board (PAB) is comprised of ten voluntary members, ranging from patient representatives, to patient involvement experts, and ethics experts. The PAB is commited to deliver a patient-centric approach ensuring that patients are represented from the beginning of the therapy development. The patients are actively involved in discussions throughout the project and assist in shaping
- [Hong Kong University Receives Funding to Participate in iPSpine](https://ipspine.eu/hku-receives-funding-to-participate-in-ipspine/) - iPSpotlight – May 27, 2019 Hong Kong University (HKU) has received funding from the EU-HK Research and Innovation cooperation co-funding mechanism by the Research Grants Council (RGC). A vital part of iPSpine’s consortium, HKU’s role is now further solidified. Professors Danny Chan and Pengtao Liu provide valuable contribution through their unique expertise in developmental biology
- [UBern Wins Poster Prize at TERMIS!](https://ipspine.eu/ubern-wins-poster-prize-at-termis/) - iPSpotlight – June 24, 2019 Work done by Dr. Daniela Frauchiger et al., from the lab of Prof. Dr. Benjamin Gantenbein’s at the University of Bern won a 2nd place poster award at TERMIS-EU 2019 in Rhodes, Greece. TERMIS is a renown meeting where scientists from all over the world meet and share scientific findings
- [Fifteen million euros towards solving chronic back pain](https://ipspine.eu/fifteen-million-euros-towards-solving-chronic-back-pain/) - Hundreds of millions of people all over the world have chronic back pain, while there still is no adequate treatment or medication for this. Professor of Regenerative Orthopedics Marianna Tryfonidou wants to change that. First in dogs, later in humans. She has founded a consortium of twenty partners, iPSpine, and will now receive a grant
- [The Faces of iPSpine](https://ipspine.eu/elementor-1246/) - In ‘The faces of iPSpine’ the members of the consortium will be introduced. Learn more about the members, their contribution to the project and their opinion towards the research. Read More
- [Learn iPSpine: biomaterials and stem cells](https://ipspine.eu/learn-ipspine-biomaterials-and-stem-cells/) - The iPSpine therapy will be comprised of special stem cells mixed with biomaterials, which help them thrive in the spine. Our friends at CÚRAM, SFI Research Centre for Medical Devices, have developed a unique set of powerpoint slides that cover the basics of biomaterials and stem cells. Learn more by downloading the slides here! Thanks CÚRAM!
- [New collaboration with RESPINE ](https://ipspine.eu/new-collaboration-with-respine/) - Last month we have started a collaboration with the RESPINE cel thearpy in clinical trial phase, to increase the impact of both projects and to support each other during the project life time and after. Many of our consortium partners are involved in both projects including Université de Nantes, University of Montpellier, NUIG, UCBM. Read more
- [iPSpine animation launched at second annual consortium meeting](https://ipspine.eu/elementor-1250/) - On the 29th and 30th of January 2020, the second annual consortium meeting of the iPSpine project was held in Nantes, France. iPSpine is a 5-year project aiming to design a novel therapy for chronic lower back pain related to disc degeneration. This therapy will use advanced stem cells and smart biomaterials that can rejuvenate
- [Inauguration of iPSpine Project Coordinator](https://ipspine.eu/inauguration-of-ipspine-project-coordinator/) - A big congratulations to our iPSpine Project Coordinator, Marianna Tryfonidou, who was inaugurated this summer! Read more about her inaugural speech from the UMCU regenerative medicine blog here: https://rmscientist.blog/2019/07/19/one-health-one-medicine-and-two-new-professors/ And to find out more about the coordinator herself, check out this interview with her:https://rmscientist.blog/2019/07/22/meet-prof-marianna-tryfonidou/
- [iPSpine Kicked-off!](https://ipspine.eu/random-title-about-random-news-event/) - On February 12th and 13th, the kick-off of an international, 15-million-euro, 20-partner project titled iPSpine(Induced pluripotent stem cell-based therapy for spinal regeneration) was held in Utrecht, The Netherlands. This 5-year project falls under the European Union’s Horizon 2020 programme to fund research that improves knowledge, testing, and exploitation platforms that address the future of advanced

## Pages

- [Homepage](https://ipspine.eu/) - Chronic lower back pain (LBP) is the leading cause of disability and morbidity worldwide. More than 700 million people globally of all ages are affected each year. LBP is a major cause of reduced activity and work absence, and imposes an economic burden of nearly ~€240 billion every year in the EU. iPSpine aims to
- [iPSpine PhD theses explainers](https://ipspine.eu/ipspine-phd-theses-explainer/) - Many groundbreaking discoveries within the iPSpine project have led to the completion of PhD theses—but what stories do these theses actually tell? Recent graduates Lisanne Laagland and Xiaole Tong take us inside their research journeys, sharing the questions they pursued, and the insights they uncovered. Lisanne Laagland (in Dutch) Wist u dat chronische lage rugpijn
- [PAB Summary](https://ipspine.eu/pab-summary-month-24/) - July 31st, 2024The iPSpine Patient Advisory Board (PAB) was established to assist the consortium in aligning the project outcomes with patient needs. This meant helping the consortium define what these needs were, how to optimally address them, and inform patients on the project results. To that end, the PAB enabled the active interaction of patients
- [iPSpine Newsletter](https://ipspine.eu/ipspine-newsletter-3/)
- [iPSpine Patient Symposium](https://ipspine.eu/ipspine-patient-symposium/) - What does the current treatment landscape for lower back pain look like and what are the challenges? Is there a cure for chronic back pain on the horizon? On Tuesday April 16th, lower back pain patients, researchers and medical professionals came together to address these topics and to learn more about the recent advances of
- [Summary of Progress (54 month)](https://ipspine.eu/summary-of-progress-54-month/) - Are you suffering from low back pain? You’re not alone—low back pain is a major cause of disability worldwide. A key factor contributing to this pain is the degeneration of the discs in your spine, accounting for about 40% of all cases. In many of these cases this pain will pass, but unfortunately in 5%
- [Patient Advisory Board (PAB)](https://ipspine.eu/patients/) - The Patient Advisory Board (PAB) is comprised of ten members, including patient representatives, patient engagement experts, and ethicists. The PAB is commited to deliver a patient-centric approach ensuring that patients are represented from the beginning of the therapy development. The patients are actively involved in discussions throughout the project and assist in shaping iPSpine programs, services
- [The Faces of iPSpine](https://ipspine.eu/the-faces-of-ipspine/) - sheffield hallam university At Sheffield Hallam University, Prof. Christine Le Maitre and Prof. Chris Sammon have created a strong team to contribute towards an injectable hydrogel for the regeneration of the intervertebral disc. With a great understanding of the pathogenesis of disc degeneration and expertise in the fabrication of smart biomaterials, their team has been able to develop an injectable hydrogel that
- [The Faces of iPSpine - PharmaLex](https://ipspine.eu/the-faces-of-ipspine-pharmalex/) - PharmaLex What is your team's main scientific expertise/contribution to the iPSpine project? Thinking ahead on how the future iPSpine product can eventually be authorised, we support the project with regulatory advice and organize early interactions with relevant health authorities. In our conducted and planned scientific advice meetings, we clarify questions such as: Into which ATMP
- [Educational Materials](https://ipspine.eu/educational-materials/) - Regulatory Courses Biomaterials Training Biomaterials Courses iPSC Courses
- [Biomaterial Regulation](https://ipspine.eu/biomaterial-regulation/) - Medical Devices Regulatory Concepts Speakers: Javier Varela and Dr. Gonzalo ArévaloAudience: For scientists and other persons interested in learning (more) about iPSCTopics: Regulatory Framework Documentation Requirements for a Product as a Stand-Alone Medical Device or as Part of a Combined ATMPBiocompatibility Requirements Applicable to Biomaterials when Developed as Medical Devices
- [Contact](https://ipspine.eu/contact/) - Christopher Kruger, MScCommunication and Dissemination Jessie Rietdijk, MSc Project Management Annika de Jong, PhDProject Management Contact us at ipspine@catalyze-group.com
- [Patients](https://ipspine.eu/patientz/)
- [Catalyze](https://ipspine.eu/elementor-2503/) - Catalyze is a Dutch SME specialized in project management and administration for EU-level R&D projects. Catalyze has strong expertise in collaborative academic projects, scientific research, translational research, product development, clinical research, regulatory and commercial strategies in the area of pharmaceuticals, biotechnology, life sciences, and medical devices. Catalyze has experience in project management of international collaborative
- [Links & Resources](https://ipspine.eu/patientz/patients-links-resources/) - Links ReumaNederland (Dutch Arthritis Society)Fondation Arthritis (French Arthritis Society) Resources The iPSpine therapy will be a mixture of special stem cells and biomaterials, which help them thrive in the spine. Our friends at CÚRAM, SFI Research Centre for Medical Devices, have developed a unique set of powerpoint slides that cover the basics of biomaterials and
- [Links & Resources](https://ipspine.eu/partners/partners-links-resources/) - Resources Logo Color Black and White iPSpine ppt template Societies and organizations: Orthopedic Research Society TERMIS OARSI ISSLS Biospine
- [Virtual Lab Tours](https://ipspine.eu/virtual-lab-tours/) - Meet our researchers! Lisanne Laagland (Utrecht University) Lisanne shows her workplace in the stem cell culture lab at Utrecht University. She tells us about the equipment she works with, and shows what the stem cells look like under a microscope. Rebecca Williams (Sheffield Hallam University) Rebecca explains her work at the Tissue Engineering and Biomechanics
- [iPSC Courses](https://ipspine.eu/educational-materials/ipsc-courses/) - 1. Not to lose control over iPSC deciding for their fate (iPSC background) Speaker: Dr. Anne CamusAudience: For scientists and other persons interested in learning (more) about iPSCTopics: iPSC differentiation Lineage SpecificationControl of cell fate for IVD regenerative medicine
- [Frequently Asked Questions (FAQ)](https://ipspine.eu/frequently-asked-questions/) - iPSpine therapy Why does iPSpine develop an advance stem cell therapy? Currently, for patients suffering from lower back pain in the US and in Europe cell therapies that are available employ the “classic” stem cells. These are stem cells that are isolated for example from the bone marrow or fat tissue. They are being broadly
- [Biomaterials Courses](https://ipspine.eu/biomaterials-courses/) - 1. Introduction to Biomaterials Speaker: Dr. Merari ChevalierAudience: For scientists and other persons interested in learning about biomaterialsTopics: Definitions Natural vs syntheticForms & Structures 2. Physico-chemical Characterization of Hydrogels Speaker: Dr. Sergio Martin SaldañaAudience: For scientists and other persons interested in learning about biomaterialsTopics: RheologyDegradation 3. Cell Response Speaker: Georgina Targa FabraAudience: For scientists and other persons interested in learning about
- [Regulatory Courses](https://ipspine.eu/regulatory-courses/) - 1. Introduction to Advanced Therapy Medicinal Products (ATMPs) Audience: For scientists, regulatory affairs managers, and other persons interested in learning about regulatory affairs principles, the development and marketing authorisation of Advanced Therapy Medicinal Products (ATMPs) in the EU.Aims: This webinar is an introduction to relevant categories of regulatory documents and regulatory Agencies in the EU
- [Patient Stories](https://ipspine.eu/patient-stories/) - Zoë Bacon “My back pain first started when I was 14. I had been on a dog walk with my family, and after we had driven home, I suddenly realised I couldn’t move my legs.” Rian de Brouwer “My lower backpain started when I was seventeen years old and it wasn’t exactly a subtle introduction.
- [Patient Stories - Nikola Skoro](https://ipspine.eu/patient-stories-nikola-skoro/) - On several occasions, I was caught in the middle of a movement, like getting up from a seat, and could not get either further up or back into the seated position. Nikola Skoro Patient Usually being a sportsman, like being into martial arts (Karate and Aikido), cycling and playing American Football semi-professionally (Linz Steelers, Austria),
- [Patient Stories - Koert Hommel](https://ipspine.eu/patient-stories-koert-hommel/) - I discovered the “multidisciplinary approach to chronic pain”: combining a medical search with researching your entire body and mind. That knowledge started a change, a shift, in my thinking. Koert Hommel Member of the ipspine patient advisory board My patient story is about meaningfulness in life. And about an overwhelming pain in my left leg
- [Faces of iPSpine - Ubern](https://ipspine.eu/faces-of-ipspine-ubern/) - Ubern What is your team's main scientific expertise/contribution to the iPSpine project? The Ubern team is primarily contributing to intervertebral disc (IVD) cells that were isolated with written consent from patients undergoing spinal surgery. These cells were collected from peripheral blood and from the removed IVD tissue during discectomy surgery. Dr. Julien Guerrero, the post-doctoral researcher in my
- [iPSpine Approach](https://ipspine.eu/project/ipspine-approach/) - The project will begin in the lab, with the scientific development of viable stem cell and smart biomaterial. These will be combined and tested in a battery of testing platforms that mimic the diseased environment. Finally, cellular and clinically relevant animal models will be used to test for translation and safety, culminating in a proof-of-concept study in canines.
- [The Faces of iPSpine - Sheffield Hallam Univeristy](https://ipspine.eu/the-faces-of-ipspine-2/) - Sheffield Hallam Univeristy What is your team's main scientific expertise/contribution to the iPSpine project? With nearly 20 years of experience in researching the pathogenesis of disc degeneration. We have characterised the changes which occur during disc degeneration in the cells of the diseased disc. The advanced cell therapy developed in iPSpine (iPS-NLCs) is intended to
- [The Faces of iPSpine - INSERM](https://ipspine.eu/the-faces-of-ipspine-3/) - INSERM What is your team's main scientific expertise/contribution to the iPSpine project? My main expertise is focused on the use of stem cells for tissue engineering and cell therapy approaches in osteo-articular diseases. In addition to conduct research projects, I am also the scientific leader of the EcellFrance platform on pre-clinical and safety evaluation models.
- [The Faces of iPSpine - NTrans Technology](https://ipspine.eu/the-faces-of-ipspine-4/) - NTrans Techology What is your team's main scientific expertise/contribution to the iPSpine project? Virus-free modification of iPSCs with our iTOP technology.With iTOP we can deliver native proteins in to cells using a natural cellular uptake pathway. We will further develop and optimize our​ iTOP technology to allow efficient intracellular delivery of gene- or epigenetic modifying enzymes into
- [Links](https://ipspine.eu/patientz/links/) - ReumaNederland (Dutch Arthritis Society) Fondation Arthritis (French Arthritis Society)
- [Background](https://ipspine.eu/project/background/) - Chronic lower back pain (LBP) is a leading cause of disability and morbidity worldwide.. Although there are many causes of LBP, one major cause is the degeneration of the spine’s intervertebral discs (IVDs). This condition makes up around 40%, or 280 million, LBP cases. This leads to an economic burden in the EU of around ~€240 billion. Despite the large impact, patients with this type
- [Achtergrond](https://ipspine.eu/nl/achtergrond/) - Chronische lage rugpijn is wereldwijd een van de belangrijkste oorzaken van invaliditeit en morbiditeit. Hoewel lage rugpijn vele oorzaken kent, is een belangrijke oorzaak de beschadiging van de tussenwervelschijven van de wervelkolom. Deze betreft ongeveer 40% – of 280 miljoen – van de gevallen. Dit leidt in de EU tot een economische last van ongeveer
- [Patient Stories - Rian de Brouwer](https://ipspine.eu/patient-stories-rian-de-brouwer/) - My hope is that iPSpine will make the change in the lower back pain therapy field. Rian de Brouwer member of the ipspine patient advisory board Dear lower back pain patient,I’m writing my story for everybody who is willing to read it (thank you), but in the first place I’m writing to you. Why? Because, you and
- [Patient Stories - Anne Harrison](https://ipspine.eu/patient-stories-anne-harrison/) - By sharing my story and joining the PAB I feel I can make a valuable contribution to understanding the complexities of LBP. Anne Harrison Member of the ipspine patient advisory board Hello, my name is Anne Harrison, I am 64 years old. I am a very active person and my interests are walking, gardening, horse
- [Patient stories - Zoë Bacon](https://ipspine.eu/patient-stories-zoe-bacon/) - The main advice I would give to someone in the same position as me would be don’t let it stop you doing anything! Zoë Bacon MEDICAL ENGINEER I am 21 years old from London. I am a medical engineer and I love windsurfing. I also enjoy playing the piano and volunteering in my local hospital.My
- [Animation](https://ipspine.eu/patient-animation/)
- [The Faces of iPSpine](https://ipspine.eu/project/faces-of-ipspine/) - In ‘The faces of iPSpine’ the members of the consortium will be introduced. Learn more about the members, their contribution to the project and their opinion towards the research. Read More
- [Christine Le Maitre](https://ipspine.eu/project/faces-of-ipspine/thefacesofipspine-christinelemaitre/) - The Faces of iPSpine Christine le maitre Professor of Cell Biology and Tissue Regeneration, in the Biomolecular Sciences Research Centre of Sheffield Hallam Univeristy. Contribution to the ipspine project Working in this consortium Being part of the unique project What is your team’s main scientific expertise/contribution to the iPSpine project? With nearly 20 years of
- [Privacy Statement](https://ipspine.eu/privacy-statement/) - STATISTICS To ascertain which parts of our website interest visitors most, we use third-party software to keep constant track of how many visitors access our site and which elements are viewed most often. The resulting data is used to generate statistics. Using this information, we can ensure that the website structure, navigation and content are
- [背景](https://ipspine.eu/zh/背景/) - 慢性腰背痛在全世界都是影响身体健康并引致残疾的主要原因。虽然其原因有多种，但脊柱椎间盘退化起主要作用，影响约四成也就是2亿8千万位病患，在欧盟内造成约2千4百亿欧元的沉重经济负担。尽管其影响至巨，罹患此类腰背痛的病人的治疗选项并不多，只能止痛及接受物理治疗。如果仍然无济于事，最后的选项就是昂贵并具侵入性的外科手术。目前仍无任何疗法可停止或逆转病变。对于慢性腰背痛，可能达到的最好治疗就是镇痛并使已退化的组织再生，从而达致长期疗效。 iPSpine的合作方包括多所大学和公司。我们将共同合作，启动对因椎间盘退化而引起的腰背痛的新进治疗方案的研究。本课题的目标是利用一类称为诱导性多能干细胞（iPSC）的细胞研究并开发一种新的进阶生物治疗方案。来自血液或皮肤的成熟细胞将经过重新编程发育为脊柱细胞。以此方法可用少数成熟细胞制造大量的iPSC细胞，这些iPSC再被分化为椎间盘细胞，以便重新占据已退化的原有细胞的位置。今后五年，iPSpine的合作各方希望证明将iPSC细胞用于此类治疗的可行性。初期我们将在实验室内开展基础研究以制造此类细胞，随后将在动物模型中开展临床前研究。在课题结束阶段，有关的新疗法将基本就绪，准备进入第一个人体临床试验。 iPSpine的影响: iPSpine希望为有关此类疾病的进阶治疗方案的研究提供新技术。以脊柱椎间盘退化为例，iPSpine期待持续减少腰背痛的困扰，避免患者因腰背痛而提早退休，从而为数以百万计的患者带来福音，使他们的生活质量有所提高，并取得更好的社会经济效益。
- [Hintergrund](https://ipspine.eu/de/hintergrund/) - Chronische Rückenschmerzen an der Lendenwirbelsäule (LWS) gelten weltweit als eine der Hauptursachen für Krankheit und Arbeitsunfähigkeit. Die Degeneration der Bandscheiben gilt neben vielen anderen Ursachen als einer der Hauptgründe für Rückenschmerzen. Etwa 40% der Fälle (280 Mio.) sind darauf zurückzuführen und verursachen EU-weit einen wirtschaftlichen Verlust von rund 240 Mrd. Euro. Trotz der großen Bedeutung
- [Contexte](https://ipspine.eu/fr/contexte/) - Les douleurs lombaires chroniques ou lombalgies sont une des principales causes d'invalidité chez l’adulte et de morbidité dans le monde. Bien qu'il existe de nombreuses causes de lombalgie, l'une des principales est la dégénérescence des disques intervertébraux (DIV) de la colonne vertébrale. Cette dégénérescence des DIV explique environ 40% des cas de lombalgie soit environ
- [Sfondo](https://ipspine.eu/it/703-2/) - La lombalgia cronica (LBP) è una delle principali cause di disabilità in tutto il mondo. Anche se esistono diverse cause di LBP, una delle cause principali è la degenerazione dei dischi intervertebrali della colonna vertebrale. Questa condizione rappresenta circa il 40%, o 280 milioni, di casi di LBP. Ciò comporta una spesa economica per l’Unione
- [Learn more](https://ipspine.eu/patientz/learn-more/) - More information about the study will be available soon! For now, please follow us on twitter @iPSpine
- [Meer informatie](https://ipspine.eu/nl/meer-informatie/) - Meer informatie zal binnenkort beschikbaar zijn! Volg ons voorlopig op Twitter @iPSpinehttps://twitter.com/iPSpine
- [Links](https://ipspine.eu/nl/links/) - Nederlands: Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque varius ut enim ut ultrices. Etiam eget sem eu elit venenatis mollis vel eu dui. Nulla risus neque, viverra eget justo tincidunt, efficitur molestie nisi. Ut rutrum nisl vel aliquam sagittis. Sed vitae metus sem. Quisque at magna venenatis, ornare augue ut, lacinia nulla. Pellentesque
- [Nieuwsbrief](https://ipspine.eu/nl/nieuwsbrief/) - Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque varius ut enim ut ultrices. Etiam eget sem eu elit venenatis mollis vel eu dui. Nulla risus neque, viverra eget justo tincidunt, efficitur molestie nisi. Ut rutrum nisl vel aliquam sagittis. Sed vitae metus sem. Quisque at magna venenatis, ornare augue ut, lacinia nulla. Pellentesque in
- [Publications](https://ipspine.eu/publications/)
- [Partners](https://ipspine.eu/partners/)
- [Project](https://ipspine.eu/project/)
- [Sample Page](https://ipspine.eu/sample-page/) - This is an example page. It's different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say something like this: Hi there! I'm a bike messenger

## My Templates

- [Buttons](https://ipspine.eu/?elementor_library=buttons) - NWO-ARC Awards 2020/21 Learn more
- [Default Kit](https://ipspine.eu/?elementor_library=default-kit)
- [3 Buttons Section](https://ipspine.eu/?elementor_library=3-buttons-section) - NWO Talent Programme Learn more iPSpine Research Approach Learn More
- [ipspine links to share](https://ipspine.eu/?elementor_library=ipspine-links-to-share) - Twitter LinkedIn Facebook Email WhatsApp
- [Faces of iPSpine](https://ipspine.eu/?elementor_library=faces-of-ipspine) - NTrans Techology What is your team's main scientific expertise/contribution to the iPSpine project? Virus-free modification of iPSCs with our iTOP technology.With iTOP we can deliver native proteins in to cells using a natural cellular uptake pathway. We will further develop and optimize our​ iTOP technology to allow efficient intracellular delivery of gene- or epigenetic modifying enzymes into
- [Summary](https://ipspine.eu/?elementor_library=summary) - A strong evidence base for the effective and safe use of iPSC-based strategies for treatment of intervertebral disc degeneration (IDD). The past period the consortium worked on the different key elements necessary for the development of the therapy (i.e., cells and biomaterials) and the technology to provide robust evidence on safety and efficacy of the

## Events

- [Eurospine 2021](https://ipspine.eu/event/eurospine-2021/)
- [EUROSPINE Spring Webinars 2021](https://ipspine.eu/event/eurospine-spring-webinars-2021/)
- [NASS 36th annual meeting](https://ipspine.eu/event/nass-36th-annual-meeting/)
- [EuroSpine EduWeek](https://ipspine.eu/event/eurospine-eduweek/)
- [TERMIS](https://ipspine.eu/event/termis/) - Abstract deadline closed
- [BioSpine](https://ipspine.eu/event/biospine/)
- [OARSI](https://ipspine.eu/event/oarsi/)
- [World Biomaterials Conference](https://ipspine.eu/event/world-biomaterials-conference/)
- [World Congress Lower Back Pain](https://ipspine.eu/event/world-congress-lower-back-pain/)
- [ORS](https://ipspine.eu/event/ors-2021/)
- [BritSpine](https://ipspine.eu/event/britspine-2/)
- [Global Spine Congress](https://ipspine.eu/event/global-spine-congress/) - Deadline for abstract submission closed.
- [OARSI 2020 World Congress](https://ipspine.eu/event/oarsi-2020-world-congress/) - Deadline for abstract submission closed
- [Britspine](https://ipspine.eu/event/britspine/) - Deadline for abstract submission: 5:00pm, 11th December 2019
- [Spineweek](https://ipspine.eu/event/spineweek/) - Abstract submission closed
- [World Congress LBP](https://ipspine.eu/event/world-congress-lbp/) - Abstract submission closed
- [ESGCT 2019](https://ipspine.eu/event/esgct-2019/) - Abstract submission closed
- [ORS PSRS 5th International Spine Research Symposium](https://ipspine.eu/event/ors-psrs-5th-international-spine-research-symposium/) - Abstract submission closed.
- [eCM conference Orthopaedic Infection](https://ipspine.eu/event/launch-development-site/)
- [European Society for Biomaterials](https://ipspine.eu/event/european-society-for-biomaterials/)
- [ORS Annual Meeting 2020](https://ipspine.eu/event/ors-annual-meeting-2020/) - Deadline for abstract submission: August 26, 2019 Deadline for internal abstract submission (Teamsite): August 5, 2019
- [TERMIS-EU 2020](https://ipspine.eu/event/termis-eu-2020/) - Deadline for abstract submission: Coming soon
- [EUROSPINE 2019](https://ipspine.eu/event/eurospine-2019/) - Abstract submission closed
- [North American Spine Society](https://ipspine.eu/event/north-american-spine-society/) - Abstract submission closed
- [The Society for Back Pain Research](https://ipspine.eu/event/the-society-for-back-pain-research/)
- [European Congress of Rheumatology](https://ipspine.eu/event/launch-ipspine-eu/)

## Meetings

- [Executive Steering Committee T/C](https://ipspine.eu/meeting/first-meeting/)
- [Annual Consortium Meeting](https://ipspine.eu/meeting/third-meeting/)
- [Executive Steering Committee T/C](https://ipspine.eu/meeting/second-meeting/)

## Partners

- [NTrans Technologies (NTT)](https://ipspine.eu/consortium/ntrans-technologies-ntt-2/) - NTrans Technologies BV was founded in 2015 based on a proprietary platform technology for the intracellular delivery of CRISPR-Cas9, developed at the Hubrecht Institute of the Royal Netherlands Academy of Sciences. The iTOP intracellular delivery technology is based on a combination of small molecule compounds which forces the uptake of large gulps of extracellular fluid (containing the CRISPR-Cas9 RNP’s) by
- [National University of Ireland Galway](https://ipspine.eu/consortium/national-university-of-ireland-galway/) - The Pandit laboratory at the Centre for Research in Medical Devices (CÚRAM) has validated the efficacy of a hyaluronan hydrogel to alleviate pain, reduce nociceptive behavior, downregulate nociception markers and inhibit hyper-innervation in a novel rat model of pain induced by intervertebral disc injury. Furthermore, the hyaluronan hydrogel altered glycosylation and modulated key inflammatory and
- [Catalyze](https://ipspine.eu/consortium/catalyze-2/) - Catalyze is a Dutch SME specialized in project management and administration for EU-level R&D projects. Catalyze has strong expertise in collaborative academic projects, scientific research, translational research, product development, clinical research, regulatory and commercial strategies in the area of pharmaceuticals, biotechnology, life sciences, and medical devices. Catalyze has experience in project management of international collaborative
- [ULM University](https://ipspine.eu/consortium/ulm-university-2/) - The Universitaet Ulm (UUlm) is the youngest university in Baden-Württemberg, which was founded in 1967 as university for medicine and natural sciences. The subject spectrum has been expanded considerably since then. In recent years, it has been ranked continuously among the world’s top 15 young universities and as one of the best in Germany (Times Higher Education
- [Universiteit Utrecht](https://ipspine.eu/consortium/universiteit-utrecht-2/) - Established in 1636, Utrecht University has evolved into a leading modern comprehensive research university with a growing international reputation. On the 2017 Shanghai Academic Ranking of World Universities, Utrecht University (UU) ranks first in the Netherlands, 22th in Europe and 47th in the world. UU has an annual turnover of over 810 million euro, 34%
- [INSERM](https://ipspine.eu/consortium/inserm/) - The Inserm unit U1183 comprises four laboratories dedicated to stem cell research and immunotherapies. This unit is dedicated to innovative immunotherapies and stem cell biology and are part of the Institute for Regenerative Medicine and Biotherapy (IRMB) associates the University Hospital of Montpellier (CHU Montpellier), the INSERM and the University Montpellier (UM). UMR 1183 gathers scientist and medical
- [Université de Montpellier](https://ipspine.eu/consortium/universite-de-montpellier-2/) - Université de Montpellier (UdM) is a research-intensive university where education and research cover most of the Scientific and Technological fields. Studies at the university include: Fundamental and Applied Sciences, Human and Social Sciences (law, economy) and Health Studies. Research is structured within 72 laboratories in partnership with well-recognized research organizations such as CNRS, INSERM, IRD,
- [Université de Nantes](https://ipspine.eu/consortium/universite-de-nantes-2/) - As a major research centre in Western France, Université de Nantes comprises more than 3,200 permanent and contract research staff (teachers, researchers, scientists, administrative and technical staff, PhD students) working in laboratories accredited by the national government (63 research structures). Approximately 38,000 students (10% are foreign students) are enrolled each year, with one doctoral college composed of 8
- [NMI Research Institute](https://ipspine.eu/consortium/nmi-research-institute-2/) - The NMI Natural and Medical Sciences Institute at the University of Tübingen, based in Reutlingen/Germany, is a private not-for-profit research foundation under public law. Founded in 1985, the NMI has currently over 190 staff, and is dedicated to applied research at the interface of life sciences and material sciences. As such, its broad portfolio comprises
- [Leiden University Medical Center (LUMC)](https://ipspine.eu/consortium/leiden-university-medical-center-lumc/) - LUMC is a modern university medical center for research, education and patient care with a high quality profile and a strong scientific orientation. Its unique research practice, ranging from pure fundamental medical research to applied clinical research, places LUMC among the world top. Researchers at LUMC work together around 7 medical research profiles (MRP): Vascular
- [AO Research Institute Davos](https://ipspine.eu/consortium/ao-research-institute-davos-2/) - The AO Research Institute Davos (ARI), demonstrates excellence in applied pre-clinical Research and Development within trauma and disorders of the musculoskeletal system and in translation of this knowledge to achieve more effective patient care worldwide. The Musculoskeletal Regeneration Program is a multidisciplinary team focusing on a holistic approach to tissue engineering for repair and regeneration of
- [Universität Bern](https://ipspine.eu/consortium/universitat-bern-2/) - The University of Bern (UBERN) is a traditional European full university (with humanities, natural sciences, medicine and veterinary medicine) with around 18,000 students currently. 38% of the 2,500 PhD students come from abroad. UBERN is very experienced in managing EU Grants and has been involved in projects since FP3. For FP7 and Horizon 2020, these
- [University of Miami](https://ipspine.eu/consortium/university-of-miami-2/) - The University of Miami (UM) is private research university with more than 17,000 students from around the world. Established in 1925, UM is a major research university engaged in more than $309 million in research and sponsored program expenditures annually in areas such as medicine, engineering, education, law and ethics. UM comprises 11 schools and
- [UMC Utrecht](https://ipspine.eu/consortium/umc-utrecht/) - With over 1,100 beds and more than 11,000 employees, the University Medical Center Utrecht (UMCU) is one of the largest academic centers in the Netherlands. Patient care and biomedical research are closely linked, which creates an environment where scientific advancements quickly move from bench to bedside. At UMCU, research is focused on 7 key areas,
- [Università Campus Bio-Medico di Roma](https://ipspine.eu/consortium/universita-campus-bio-medico-di-roma/) - Università Campus Bio-Medico di Roma (UCBM) was established in 1993 with the cultural aim of restoring to the biomedical sciences the value of human life and the person as their central focus. UCBM promotes integrated teaching, research and healthcare, pursuing as the main end of all its activities the good of the human person. UCBM is now
- [The University of Hong Kong](https://ipspine.eu/consortium/the-university-of-hong-kong-2/)
- [TU/e](https://ipspine.eu/consortium/tu-e-2/) - Eindhoven University of Technology (TU/e) is a research university specializing in engineering science & technology. Its education, research and knowledge valorization contribute to 1) science for society: solving the major societal issues and boosting prosperity and welfare by focusing on the Strategic Areas of Energy, Health and Smart Mobility, 2) science for industry: the development of
- [SpineServ GmbH & Co. KG](https://ipspine.eu/consortium/spineserv-gmbh-co-kg-2/) - SpineServ specializes in mechanical testing of surgical implants, surgical instruments and implant materials. Spinal implants, osteosynthesis implants, endoprostheses and dental implants, surgical instruments, implant materials and biomaterials undergo static testing (stiffness, strength), dynamic testing (fatigue testing), wear testing or corrosion testing either according to standards (ASTM, ISO) or following custom testing procedures. Due to our
- [Sheffield Hallam University](https://ipspine.eu/consortium/sheffield-hallam-university-2/) - Prof. Dr. Marietta Kaszkin-Bettag: Biologist, Pharmacologist (Director, Head of Development Consulting & Scientific Affairs) is responsible for the management and execution of scientific and regulatory writing projects and providing advice on regulatory strategy. Her experience comprises the coordination and preparation of gap analyses of dossiers, preparation and conduct of scientific advices, preparation of all nonclinical and clinical
- [ReumaNederland](https://ipspine.eu/consortium/reuma-nederland-2/)
- [Pharmalex GmbH](https://ipspine.eu/consortium/pharmalex-gmbh/) - Founded in 1994, PharmaLex supports pharma and biotech companies as well as academia throughout the entire product lifecycle, ensuring compliance with pharmaceutical regulations and providing vital scientific and strategic advice on drug development. PharmaLex has since then conducted over 30,000 projects for over 600 clients worldwide. Our global team has more than 850 local knowledge

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